Dear Thatnewguy,
What do you want to fish for? If you are seeking trout, you may need to drive depending on exactly what you are looking to find. There is trout fishing in the SC part of the state. but it is generally better further north. You may want to check out the Cumerland Valley region in Cumberland County. There are several well-regarded trout streams over there about 45 minutes to an hour away.
There are plenty of warmwater streams and lakes to fish here though. Once the Susquehanna settles down a bit you can fish there for smallmouth. Pinchot State Park has good summertime bass and pan fishing, as do Memorial Lake State Park and Sweet Arrow Lake near Pine Grove. All of them are within an hour of NW Lancaster County. Closer to home you might want to check out Speedwell Forge Lake.
I'll suggest you check out the county guides that are available on the PA Fish ad Boat Commission website. It takes a bit of fiddling around to figure the maps out, but you can find out a lot using them especially if you aren't familiar with the area. You can select trout streams, trout lakes, special regulations, unstocked wild trout streams, etc. etc. all by using the checklist on the maps.
Here is the map, play around with it to see what you can find.
https://pfbc.maps.arcgis.com/apps/webappviewer/index.html?id=3292981a1fcf415e9ce4a4a7a3ce98e2
Feel free to ask more questions.
Regards,
Tim Murphy