I’d ask that Orvis guy how many flies they stock in his shop, and why.
When you start fishing a specific stream, at a specific time of the year, and at a specific time of the day, considering the weather, stream level and water temperature on that specific day, you MIGHT want to start out fishing one specific nymph pattern.
But, then you might also want to be prepared with different sizes and different colors of that one specific nymph pattern. Just in case. 50 or so different variations of that specific nymph might be enough to get you covered. For the first hour. Maybe.
Then the fish in that specific stream start feeding on top, on a specific fly, and the weather changes and the fish stop feeding altogether. You might want to try fishing a dry fly on top, or try something entirely different to attract their attention. A few more hundred flies in different sizes and colors might be in order.
Then, you decide to fish and entirely different stream, maybe in an entirely different geographic location, and at a different time of the year. Maybe it’s a tailwater where the fish feed heavily on size #18-#22 insects. That Orvis guy sold you just a single size #12 nymph. What to do?
Limit your flies and you limit your success. And you’ll limit your fun.